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Contact: Jennifer Gatti, 914-740-2100,
Vascular and Mechanical Stimuli Work Together to Enhance Bone Growth in Stem Cell-Based Tissue Engineering

New Rochelle, NY, December 1, 2016—A bone tissue engineering approach that exposed human stem cells in the laboratory to both growth factors that promote formation of a vascular network and to mechanical stimuli at the same time led to a significant increase in bone formation. However, neither vascular-promoting signals nor cyclic tensile strain alone enhanced osteogenesis, according to the results of a study published in Tissue Engineering, Part A, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free for download on the Tissue Engineering website until December 31, 2016.

The article "Mechanical and Vascular Cues Synergistically Enhance Osteogenesis in Human Mesenchymal Stem Cells," is coauthored by Andrew Steward, PhD, Jacqueline Cole, PhD, Frances Ligler, DPhil, DSc, and Elizabeth Loboa, PhD, University of North Carolina-Chapel Hill and North Carolina State University, Raleigh, and University of Missouri, Columbia. The researchers demonstrate that the complex interactions between bone and the surrounding vascular networks that provide oxygen, nutrients, and critical growth factors depend on both biochemical and biophysical stimuli. Their study involved the co-culture of human umbilical vein endothelial cells with mesenchymal stem cells to create tissue-engineered bone constructs with potential use in future regenerative medicine therapeutic strategies.

"This manuscript elegantly expresses the importance of polyfactorial management of the bone growth interface, a concept that is likely to extend analogously to other vascularized tissue types," says Co-Editor-in-Chief Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC.

Research reported in this publication was supported by the National Cancer Institute under Pilot Research Grant NIH/NIBIB 1R03EB008790. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

About the Journal
Tissue Engineering is an authoritative peer-reviewed journal published monthly online and in print in three parts: Part A, the flagship journal published 24 times per year; Part B: Reviews, published bimonthly, and Part C: Methods, published 12 times per year. Led by Co-Editors-In-Chief Antonios G. Mikos, PhD, Louis Calder Professor at Rice University, Houston, TX, and Peter C. Johnson, MD, Principal, MedSurgPI, LLC and President and CEO, Scintellix, LLC, Raleigh, NC, the Journal brings together scientific and medical experts in the fields of biomedical engineering, material science, molecular and cellular biology, and genetic engineering. Tissue Engineering is the official journal of the Tissue Engineering & Regenerative Medicine International Society (TERMIS). Complete tables of content and a sample issue may be viewed online at the Tissue Engineering website.

About the Publisher
Mary Ann Liebert, Inc., publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Stem Cells and Development, Human Gene Therapy, and Advances in Wound Care. Its biotechnology trade magazine, GEN (Genetic Engineering & Biotechnology News), was the first in its field and is today the industry’s most widely read publication worldwide. A complete list of the firm’s 80 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.